Nomenclature and Serology of HLA Class I and Class II Alleles

James McCluskey1, Carmel Kanaan2, Mary Diviney2

1 University of Melbourne and Australian Red Cross Blood Service, Melbourne, 2 Australian Red Cross Blood Service, Melbourne
Publication Name:  Current Protocols in Immunology
Unit Number:  Appendix A.1S
DOI:  10.1002/cpim.32
Online Posting Date:  August, 2017
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Abstract

This overview presents nomenclature and serology information on human leucocyte antigens, or HLA molecules, which are encoded by a cluster of genes linked on the short arm of chromosome 6. This region is known as the major histocompatibility complex and codes for class I and class II molecules, which are distinguished from each other based upon their structure, tissue distribution, and source of peptide antigen, as well as upon their interactions with T cell subsets. © 2017 by John Wiley & Sons, Inc.

Keywords: human leucocyte antigens; HLA; major histocompatibility complex; MHC; HLA class I; HLA class II

     
 
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Table of Contents

  • Introduction
  • MHC Class I Molecules
  • MHC Class II Molecules
  • Serological Definition of Polymorphism in HLA Molecules: Historical Nomenclature
  • Supertypic Bw4 and Bw6 Serological Specificities
  • Principles of Nomenclature
  • Literature Cited
  • Figures
  • Tables
     
 
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Materials

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Figures

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Literature Cited

Literature Cited
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