Current Protocols in Nucleic Acid Chemistry

Overview

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What's New in Current Protocols in Nucleic Acid Chemistry
Supplement 47, December 2011

Unit 1.25 Synthesis of the Tellurium-Derivatized Phosphoramidites and Their Incorporation into DNA Oligonucleotides
         Abstract | Full Text:  HTML   PDF

Unit 4.47 Preparation of DNA Containing 5-Hydroxymethyl-2′-Deoxycytidine Modification Through Phosphoramidites with TBDMS as 5-Hydroxymethyl Protecting Group
         Abstract | Full Text:  HTML   PDF

Unit 7.16 Liquid Chromatography-Mass Spectrometry Analysis of DNA Polymerase Reaction Products
         Abstract | Full Text:  HTML   PDF

Unit 8.7 ICON Probes: Synthesis and DNA Methylation Typing
         Abstract | Full Text:  HTML   PDF

Unit 14.7 Synthesis of Entecavir and Its Novel Class of Analogs
         Abstract | Full Text:  HTML   PDF

Published in association with International Society for Nucleosides, Nucleotides & Nucleic Acids (IS3NA), Current Protocols in Nucleic Acid Chemistry is equally valuable for biotech, pharmaceutical, and academic labs. It is the resource for designing and running successful research projects in the rapidly growing and changing field of nucleic acid, nucleotide, and nucleoside research.

Updated every three months in all formats, CPNAC is constantly evolving to keep pace with the very latest discoveries and developments. A year of these quarterly updates is included in the initial CPNAC purchase price. That's 500 pages of new (66%) and revised (34%) content on average every year since the initial publication of the work in February 2000! Presently three volumes in its looseleaf print version, CPNAC...

• draws from a unique set of chemistries to synthesize modified nucleic acids, which can be used in structure-function studies, as therapeutic agents, and as tools for molecular biology.
• covers basic to advanced techniques for the synthesis, modification, purification, analysis, and utilization of nucleic acids, nucleotides, and nucleosides.

Edited by: Martin Egli (Vanderbilt Univesity); Piet Herdewijn (Rega Institute of Medical Research); Akira Matsuda (Hokkaido University); Yogesh S. Sanghvi (Rasayan, Inc.); Past Editors: Serge L. Beaucage; Donald E. Bergstrom; Gary D. Glick; Roger A. Jones

Developmental Editor: Ann Boyle

See is3na.org for information about the society and the 2010 International Roundtable (IRT) meeting.

While the authors, editors, and publisher believe that the specification and usage of reagents, equipment, and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they accept no legal responsibility for any errors or omissions, and make no warranty, express or implied, with respect to material contained herein. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. This is particularly important in regard to new or infrequently employed chemicals or experimental reagents. Moreover, the information presented herein is not a substitute for professional judgment, especially as concerns any applications in a clinical setting or the interpretation of results thereby obtained.