Current Protocols in Chemical Biology

Overview

What's New in Current Protocols in Chemical Biology
Volume 2, Number 3, July 2010

High-Throughput Assessment of Mammalian Cell Viability by Determination of Adenosine Triphosphate Levels
         Abstract | Full Text:  HTML   PDF

Small-Molecule Library Synthesis on Silicon-Functionalized SynPhase Lanterns
         Abstract | Full Text:  HTML   PDF

Volume 2, Number 2, June 2010

Nucleotide Analogues as Probes for DNA and RNA Polymerases
         Abstract | Full Text:  HTML   PDF

Site-Specific Protein Bioconjugation via a Pyridoxal 5'-Phosphate-Mediated N-Terminal Transamination Reaction
         Abstract | Full Text:  HTML   PDF

Volume 2, Number 2, May 2010

Directed Evolution of DNA Polymerases: Construction and Screening of DNA Polymerase Mutant Libraries
         Abstract | Full Text:  HTML   PDF

New in 2010, Current Protocols in Chemical Biology provides validated protocols and enlightening overviews for researchers requiring specialized chemical techniques and tools for their studies of biology and drug design. Current Protocols in Chemical Biology describes these chemical tools, including small-molecule design, synthesis, derivatization, handling, and detection. Advances in laboratory automation, robotics, and medicinal chemistry will be described as applied to high-throughput screening (HTS) methods. Also included will be methods for modification of proteins, nucleic acids, carbohydrates and lipids for their use as tools in the study of particular biological systems. Investigators in the fields of medicinal chemistry, combinatorial chemistry, proteomics, pharmacology, biochemistry, glycobiology, chemical genetics, molecular biology, cell biology, and cytometry will find relevant, validated, state-of-the-art methods in Current Protocols in Chemical Biology.

Updated monthly online, Current Protocols in Chemical Biology will constantly evolve to keep pace with the very latest discoveries and developments.

Edited by: Adam P. Arkin, Lara Mahal, Floyd Romesberg, Kavita Shah, Caroline Shamu, and Craig Thomas

Developmental Editor: Gwen Taylor

While the authors, editors, and publisher believe that the specification and usage of reagents, equipment, and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they accept no legal responsibility for any errors or omissions, and make no warranty,express or implied, with respect to material contained herein. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. This is particularly important in regard to new or infrequently employed chemicals or experimental reagents. Moreover, the information presented herein is not a substitute for professional judgment, especially as concerns any applications in a clinical setting or the interpretation of results thereby obtained.